Expression of RUNX1-JAK2 in Human Induced Pluripotent Stem Cell-Derived Hematopoietic Cells Activates the JAK-STAT and MYC Pathways

Expression of RUNX1-JAK2 in Human Induced Pluripotent Stem Cell-Derived Hematopoietic Cells Activates the JAK-STAT and MYC Pathways

A heterogeneous genetic subtype of B-cell precursor acute lymphoblastic leukemia is driven by constitutive kinase-activation, including patients with JAK2 fusions. In our study, we model the impact of a novel JAK2 fusion protein on hematopoietic development in human induced pluripotent stem cells (h...

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Bibliographic Details
Main Authors: Klaus Fortschegger, Anna-Maria Husa, Dagmar Schinnerl, Karin Nebral, Sabine Strehl
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
leukemia
oncogenic fusion
CRISPR/Cas9
hematopoiesis
hiPSC
JAK-STAT signaling
Online Access:https://www.mdpi.com/1422-0067/22/14/7576

Internet

https://www.mdpi.com/1422-0067/22/14/7576

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