IFN-γ down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer

IFN-γ down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer

Abstract Background Pancreatic cancer is characterized by a highly immunosuppressive tumor microenvironment and evasion of immune surveillance. Although programmed cell death 1 receptor (PD-1) blockade has achieved certain success in immunogenic cancers, the responses to the PD-1 antibody are not ef...

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Bibliographic Details
Main Authors: Guoping Ding, Tao Shen, Chen Yan, Mingjie Zhang, Zhengrong Wu, Liping Cao
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Cancer
Subjects:
Interferon-γ
Nivolumab
Programmed cell death 1 receptor
T-lymphocytes
Pancreatic cancer
Online Access:http://link.springer.com/article/10.1186/s12885-019-6145-8

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http://link.springer.com/article/10.1186/s12885-019-6145-8

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