Loss of tau rescues inflammation-mediated neurodegeneration

Loss of tau rescues inflammation-mediated neurodegeneration

Neuroinflammation is one of the neuropathological hallmarks of Alzheimer’s disease (AD) and related tauopathies. Activated microglia spatially coexist with microtubule-associated protein tau (Mapt or tau)-burdened neurons in the brains of human AD and non-AD tauopathies. Numerous studies have sugges...

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Bibliographic Details
Main Authors: Nicole eMaphis, Guixiang eXu, Olga Nicole Kokiko-Cochran, Astrid E Cardona, Richard M. Rasohoff, Bruce T. Lamb, Kiran eBhaskar
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Neuroscience
Subjects:
Microglia
Tauopathies
neurodegeneration
Alzheimer’s disease
Neuroinflammation
tau protein
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00196/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00196/full

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