BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming.

BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming.

The transport of antigen from the periphery to the draining lymph node (DLN) is critical for T-cell priming but remains poorly studied during infection with Mycobacterium bovis Bacille Calmette-Guérin (BCG). To address this we employed a mouse model to track the traffic of Dendritic cells (DCs) and...

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Bibliographic Details
Main Authors: Vishnu Priya Bollampalli, Lívia Harumi Yamashiro, Xiaogang Feng, Damiën Bierschenk, Yu Gao, Hans Blom, Birgitta Henriques-Normark, Susanne Nylén, Antonio Gigliotti Rothfuchs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4594926?pdf=render

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http://europepmc.org/articles/PMC4594926?pdf=render

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