Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2.

Pooled Resequencing of 122 Ulcerative Colitis Genes in a Large Dutch Cohort Suggests Population-Specific Associations of Rare Variants in MUC2.

Genome-wide association studies have revealed several common genetic risk variants for ulcerative colitis (UC). However, little is known about the contribution of rare, large effect genetic variants to UC susceptibility. In this study, we performed a deep targeted re-sequencing of 122 genes in Dutch...

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Bibliographic Details
Main Authors: Marijn C Visschedijk, Rudi Alberts, Soren Mucha, Patrick Deelen, Dirk J de Jong, Marieke Pierik, Lieke M Spekhorst, Floris Imhann, Andrea E van der Meulen-de Jong, C Janneke van der Woude, Adriaan A van Bodegraven, Bas Oldenburg, Mark Löwenberg, Gerard Dijkstra, David Ellinghaus, Stefan Schreiber, Cisca Wijmenga, Initiative on Crohn and Colitis, Parelsnoer Institute, Manuel A Rivas, Andre Franke, Cleo C van Diemen, Rinse K Weersma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4973970?pdf=render

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http://europepmc.org/articles/PMC4973970?pdf=render

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