Interaction of silymarin components and their sulfate metabolites with human serum albumin and cytochrome P450 (2C9, 2C19, 2D6, and 3A4) enzymes

Interaction of silymarin components and their sulfate metabolites with human serum albumin and cytochrome P450 (2C9, 2C19, 2D6, and 3A4) enzymes

Silymarin is a mixture of flavonolignans isolated from the fruit of milk thistle (Silybum marianum (L.) Gaertner). Milk thistle extract is the active ingredient of several medications and dietary supplements to treat liver injury/diseases. After the oral administration, flavonolignans are extensivel...

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Bibliographic Details
Main Authors: Zelma Faisal, Violetta Mohos, Eszter Fliszár-Nyúl, Kateřina Valentová, Kristýna Káňová, Beáta Lemli, Sándor Kunsági-Máté, Miklós Poór
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Silymarin
Sulfate conjugates
Human serum albumin
Cytochrome P450
Pharmacokinetic interaction
Herb-drug interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221002444

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http://www.sciencedirect.com/science/article/pii/S0753332221002444

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