Interaction of Purinergic P2X4 and P2X7 Receptor Subunits

Interaction of Purinergic P2X4 and P2X7 Receptor Subunits

P2X4 and P2X7 are members of the P2X receptor family, comprising seven isoforms (P2X1–P2X7) that form homo- and heterotrimeric non-specific cation channels gated by extracellular ATP. P2X4 and P2X7 are widely coexpressed, particularly in secretory epithelial cells and immune and inflammatory cells,...

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Bibliographic Details
Main Authors: Markus Schneider, Kirsten Prudic, Anja Pippel, Manuela Klapperstück, Ursula Braam, Christa E. Müller, Günther Schmalzing, Fritz Markwardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
P2X7
P2X4
voltage clamp
fluorescence
FRET
interaction
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00860/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00860/full

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