Synthesis and biological evaluation of novel N-(piperazin-1-yl)alkyl-1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid as potential MEK inhibitors

Synthesis and biological evaluation of novel N-(piperazin-1-yl)alkyl-1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid as potential MEK inhibitors

In this paper, a series of novel 1H-dibenzo[a,c]carbazole derivatives of dehydroabietic acid bearing different N-(piperazin-1-yl)alkyl side chains were designed, synthesised and evaluated for their in vitro anticancer activities against three human hepatocarcinoma cell lines (SMMC-7721, HepG2 and He...

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Bibliographic Details
Main Authors: Hao Chen, Chao Qiao, Ting-Ting Miao, A-Liang Li, Wen-Yan Wang, Wen Gu
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
dehydroabietic acid
anticancer activity
mek inhibitor
oncosis
apoptosis
Online Access:http://dx.doi.org/10.1080/14756366.2019.1655407

Internet

http://dx.doi.org/10.1080/14756366.2019.1655407

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