Chimeric Porcine Deltacoronaviruses with Sparrow Coronavirus Spike Protein or the Receptor-Binding Domain Infect Pigs but Lose Virulence and Intestinal Tropism

Chimeric Porcine Deltacoronaviruses with Sparrow Coronavirus Spike Protein or the Receptor-Binding Domain Infect Pigs but Lose Virulence and Intestinal Tropism

Porcine deltacoronavirus (PDCoV) strain OH-FD22 infects poultry and shares high nucleotide identity with sparrow-origin deltacoronaviruses (SpDCoV) ISU73347 and HKU17 strains. We hypothesized that the spike (S) protein or receptor-binding domain (RBD) from these SpDCoVs would alter the host and tiss...

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Bibliographic Details
Main Authors: Xiaoyu Niu, Yixuan J. Hou, Kwonil Jung, Fanzhi Kong, Linda J. Saif, Qiuhong Wang
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Viruses
Subjects:
porcine deltacoronavirus
S protein
reverse genetics
tissue tropism
spillover
Online Access:https://www.mdpi.com/1999-4915/13/1/122

Internet

https://www.mdpi.com/1999-4915/13/1/122

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