Squamosamide Derivative FLZ Diminishes Aberrant Mitochondrial Fission by Inhibiting Dynamin-Related Protein 1

Squamosamide Derivative FLZ Diminishes Aberrant Mitochondrial Fission by Inhibiting Dynamin-Related Protein 1

Mitochondrial dysfunction is involved in the pathogenesis of Parkinson’s disease (PD). Mitochondrial morphology is dynamic and precisely regulated by mitochondrial fission and fusion machinery. Aberrant mitochondrial fragmentation, which can result in cell death, is controlled by the mitochondrial f...

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Bibliographic Details
Main Authors: Hanyu Yang, Lu Wang, Caixia Zang, Xu Yang, Xiuqi Bao, Junmei Shang, Zihong Zhang, Hui Liu, Cheng Ju, Fangyuan Li, Fangyu Yuan, Dan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
mitochondrial dyanmics
DRP1
FLZ
mpp+
Parkinson’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.588003/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.588003/full

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