Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target

Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target

Abstract Background Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, the inhibitor of CDK4 has been used clinically under FDA approval for app...

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Bibliographic Details
Main Authors: Zhengxiao Ouyang, Sisi Wang, Ming Zeng, Zhihong Li, Qing Zhang, Wanchun Wang, Tang Liu
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Cell Communication and Signaling
Subjects:
Chondrosarocma
CDK4
Palbociclib
Rb
Target therapy
Online Access:http://link.springer.com/article/10.1186/s12964-019-0327-5

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http://link.springer.com/article/10.1186/s12964-019-0327-5

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