Perfluorophenyl Derivatives as Unsymmetrical Linkers for Solid Phase Conjugation

Linkers play major roles in conjugation chemistry toward the advancement of drug discovery. Two different series of fluorinated linkers were introduced to the backbone of a model peptide using solid phase peptide synthesis. These fluorinated linkers have the potential to conjugate two asymmetrical g...

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Bibliographic Details
Main Authors: Saba Alapour, Anamika Sharma, Beatriz G. de la Torre, Deresh Ramjugernath, Neil A. Koorbanally, Fernando Albericio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00589/full