Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation

Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation

Abstract Background Accumulating evidence indicated that necroptosis plays an essential role in the pathogenesis of inflammatory bowel disease (IBD). The O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) of necroptotic signal molecule receptor-interacting serine-threonine kinase 3 (RIPK3) was r...

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Bibliographic Details
Main Authors: Fan Wu, Qingqing Shao, Zhe Cheng, Xinyu Xiong, Ke Fang, Yan Zhao, Ruolan Dong, Lijun Xu, Fuer Lu, Guang Chen
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Chinese Medicine
Subjects:
Wu-Mei-Wan
Colitis
Necroptosis
O-GlcNAcylation
RIPK3
Online Access:https://doi.org/10.1186/s13020-021-00493-4

Internet

https://doi.org/10.1186/s13020-021-00493-4

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