Mining the human phenome using allelic scores that index biological intermediates.

Mining the human phenome using allelic scores that index biological intermediates.

It is common practice in genome-wide association studies (GWAS) to focus on the relationship between disease risk and genetic variants one marker at a time. When relevant genes are identified it is often possible to implicate biological intermediates and pathways likely to be involved in disease aet...

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Bibliographic Details
Main Authors: David M Evans, Marie Jo A Brion, Lavinia Paternoster, John P Kemp, George McMahon, Marcus Munafò, John B Whitfield, Sarah E Medland, Grant W Montgomery, GIANT Consortium, CRP Consortium, TAG Consortium, Nicholas J Timpson, Beate St Pourcain, Debbie A Lawlor, Nicholas G Martin, Abbas Dehghan, Joel Hirschhorn, George Davey Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3814299?pdf=render

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http://europepmc.org/articles/PMC3814299?pdf=render

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