High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease

High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease

Type 2 diabetes (T2DM) and obesity might increase the risk for AD by 2-fold. Different attempts to model the effect of diet-induced diabetes on AD pathology in transgenic animal models, resulted in opposite conclusions. Here, we used a novel knock-in mouse model for AD, which, differently from other...

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Bibliographic Details
Main Authors: Isabel H. Salas, Akila Weerasekera, Tariq Ahmed, Zsuzsanna Callaerts-Vegh, Uwe Himmelreich, Rudi D'Hooge, Detlef Balschun, Takaomi C. Saido, Bart De Strooper, Carlos G. Dotti
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Neurobiology of Disease
Subjects:
Alzheimer disease
Type 2 diabetes
Metabolic stress
Behavior
Electrophysiology
Magnetic resonance spectroscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300330

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http://www.sciencedirect.com/science/article/pii/S0969996118300330

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