Synthesis, Antibacterial Evaluation and QSAR of α-Substituted-N4-Acetamides of Ciprofloxacin and Norfloxacin

Synthesis, Antibacterial Evaluation and QSAR of α-Substituted-N4-Acetamides of Ciprofloxacin and Norfloxacin

Twenty six α-substituted N4-acetamide derivatives of ciprofloxacin (CIPRO) and norfloxacin (NOR) were synthesized and assayed for antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Bacillus subtilis. The derivatives were primarily more active against G...

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Bibliographic Details
Main Authors: Amjad M. Qandil, Lorca O. Al-Zoubi, Amal G. Al-Bakri, Haneen A. Amawi, Qosay A. Al-Balas, Abdulmalik M. Alkatheri, Abdulkareem M. Albekairy
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Antibiotics
Subjects:
antibacterial activity
drug design
Gram-positive bacteria
QSAR
quinolones
synthesis
Online Access:http://www.mdpi.com/2079-6382/3/3/244

Internet

http://www.mdpi.com/2079-6382/3/3/244

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