Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

Abstract Background Amplification of chromosome 7q21-7q31 is associated with tumor recurrence and multidrug resistance, and several genes in this region are powerful drivers of hepatocellular carcinoma (HCC). We aimed to investigate the key circular RNAs (circRNAs) in this region that regulate the i...

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Bibliographic Details
Main Authors: Xiao-Yong Huang, Peng-Fei Zhang, Chuan-Yuan Wei, Rui Peng, Jia-Cheng Lu, Chao Gao, Jia-Bing Cai, Xuan Yang, Jia Fan, Ai-Wu Ke, Jian Zhou, Guo-Ming Shi
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Molecular Cancer
Subjects:
Hepatocellular carcinogenesis
circRNA
miR-30-5p
circMET
DPP4
Online Access:http://link.springer.com/article/10.1186/s12943-020-01213-6

Internet

http://link.springer.com/article/10.1186/s12943-020-01213-6

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