An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source

An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source

Ultrasound-promoted N-aminomethylation of indoles can be achieved in basic medium using sodium hydride and dichloromethane (DCM) as C1 donor source. This innovative amino methylation protocol results in good to excellent yields of multifunctional indole derivatives. The procedure is also applicable...

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Bibliographic Details
Main Authors: Carmine Ostacolo, Veronica Di Sarno, Simona Musella, Tania Ciaglia, Vincenzo Vestuto, Giacomo Pepe, Fabrizio Merciai, Pietro Campiglia, Isabel M. Gomez Monterrey, Alessia Bertamino
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Chemistry
Subjects:
aminomethylation
ultrasound assisted
dichloromethane
indole N-1 selectivity
aza-heterocyclic compounds
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00568/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00568/full

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