An In Vitro Whole-Organ Liver Engineering for Testing of Genetic Therapies

An In Vitro Whole-Organ Liver Engineering for Testing of Genetic Therapies

Summary: Explosion of gene therapy approaches for treating rare monogenic and common liver disorders created an urgent need for disease models able to replicate human liver cellular environment. Available models lack 3D liver structure or are unable to survive in long-term culture. We aimed to gener...

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Bibliographic Details
Main Authors: Maëlle Lorvellec, Alessandro Filippo Pellegata, Alice Maestri, Chiara Turchetta, Elena Alvarez Mediavilla, Soichi Shibuya, Brendan Jones, Federico Scottoni, Dany P. Perocheau, Andrei Claudiu Cozmescu, Juliette M. Delhove, Daniel Kysh, Asllan Gjinovci, John R. Counsell, Wendy E. Heywood, Kevin Mills, Tristan R. McKay, Paolo De Coppi, Paul Gissen
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Clinical Genetics
Bioengineering
Tissue Engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220310051

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http://www.sciencedirect.com/science/article/pii/S2589004220310051

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