High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells

High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells

High mobility group box 1 (HMGB1) is a non-histone protein which is predominantly localised in the cell nucleus. However, stressed, dying, injured or dead cells can release this protein into the extracellular matrix passively. In addition, HMGB1 release was observed in cancer and immune cells where...

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Bibliographic Details
Main Authors: Anette Teo Hansen Selnø, Stephanie Schlichtner, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Steffen M. Berger, Elena Klenova, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
galectin-9
TGF-beta 1
HMGB1 (high mobility group box 1)
immune surveillance
Toll-like receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.675731/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.675731/full

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