Cardiac Ablation of Rheb1 Induces Impaired Heart Growth, Endoplasmic Reticulum-Associated Apoptosis and Heart Failure in Infant Mice

Cardiac Ablation of Rheb1 Induces Impaired Heart Growth, Endoplasmic Reticulum-Associated Apoptosis and Heart Failure in Infant Mice

Ras homologue enriched in brain 1 (Rheb1) plays an important role in a variety of cellular processes. In this study, we investigate the role of Rheb1 in the post-natal heart. We found that deletion of the gene responsible for production of Rheb1 from cardiomyocytes of post-natal mice resulted in mal...

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Bibliographic Details
Main Authors: Yunshan Cao, Lichan Tao, Shutong Shen, Junjie Xiao, Hang Wu, Beibei Li, Xiangqi Wu, Wen Luo, Qi Xiao, Xiaoshan Hu, Hailang Liu, Junwei Nie, Shuangshuang Lu, Baiyin Yuan, Zhonglin Han, Bo Xiao, Zhongzhou Yang, Xinli Li
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:International Journal of Molecular Sciences
Subjects:
Rheb1
heart growth
infant heart failure
mTORC1
ER
Online Access:http://www.mdpi.com/1422-0067/14/12/24380

Internet

http://www.mdpi.com/1422-0067/14/12/24380

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