The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

RNA-binding proteins (RBP) are an emerging group of post-translational regulators. Here the authors show that the RBP vigilin regulates translation of mRNA encoding for proatherogenic proteins—apoB, apoC-III and fibronectin—representing a potential therapeutic target in cardiovascular diseases.

Bibliographic Details
Main Authors: Mehrpouya B. Mobin, Stefanie Gerstberger, Daniel Teupser, Benedetta Campana, Klaus Charisse, Markus H. Heim, Muthiah Manoharan, Thomas Tuschl, Markus Stoffel
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12848

Internet

https://doi.org/10.1038/ncomms12848

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