Early Steps in the Biosynthetic Pathway of Rishirilide B

Early Steps in the Biosynthetic Pathway of Rishirilide B

The biological active compound rishirilide B is produced by <i>Streptomyces bottropensis</i>. The cosmid cos4 contains the complete rishirilide B biosynthesis gene cluster. Its heterologous expression in the host <i>Streptomyces albus</i> J1074 led to the production of rishir...

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Bibliographic Details
Main Authors: Philipp Schwarzer, Olga Tsypik, Chijian Zuo, Ahmad Alali, Julia Wunsch-Palasis, Tanja Heitzler, Jana Derochfort, Mirjam Bernhardt, Xiaohui Yan, Thomas Paululat, Andreas Bechthold
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
rishirilide biosynthesis
gene deletion
streptomyces
oxygenase
ketoreductase
λ-Red/ET mediated recombination
Online Access:https://www.mdpi.com/1420-3049/25/8/1955

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https://www.mdpi.com/1420-3049/25/8/1955

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