Type II Restriction of Bacteriophage DNA With 5hmdU-Derived Base Modifications

Type II Restriction of Bacteriophage DNA With 5hmdU-Derived Base Modifications

To counteract bacterial defense systems, bacteriophages (phages) make extensive base modifications (substitutions) to block endonuclease restriction. Here we evaluated Type II restriction of three thymidine (T or 5-methyldeoxyuridine, 5mdU) modified phage genomes: Pseudomonas phage M6 with 5-(2-amin...

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Bibliographic Details
Main Authors: Kiersten Flodman, Rebecca Tsai, Michael Y. Xu, Ivan R. Corrêa, Alyssa Copelas, Yan-Jiun Lee, Ming-Qun Xu, Peter Weigele, Shuang-yong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Microbiology
Subjects:
Type II restriction and modification
5hmdU-derived nucleotide modification
Pseudomonas bacteriophage (phage) M6
Salmonella phage ViI
Delftia phi W-14
phage therapy
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00584/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00584/full

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