Chronic Carbon Tetrachloride Applications Induced Hepatocyte Apoptosis in Lipocalin 2 Null Mice Through Endoplasmic Reticulum Stress and Unfolded Protein Response

Chronic Carbon Tetrachloride Applications Induced Hepatocyte Apoptosis in Lipocalin 2 Null Mice Through Endoplasmic Reticulum Stress and Unfolded Protein Response

The lack of Lipocalin (LCN2) provokes overwhelming endoplasmic reticulum (ER) stress responses in vitro and in acute toxic liver injury models, resulting in hepatocyte apoptosis. LCN2 is an acute phase protein produced in hepatocytes in response to acute liver injuries. In line with these findings w...

Full description

Bibliographic Details
Main Authors: Erawan Borkham-Kamphorst, Ute Haas, Eddy Van de Leur, Anothai Trevanich, Ralf Weiskirchen
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
ER stress
UPR
LCN2
CHOP
hepatocyte
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/15/5230

Internet

https://www.mdpi.com/1422-0067/21/15/5230

Similar Items