SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate CellsSummary

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate CellsSummary

Background & Aims: Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that is manifested clinically by an increase in hepatic triglycerides, inflammation, and fibrosis. The pathogenesis of NASH remains incompletely understood. Sirtuin 6 (Sirt6), a nicotinamide adenine dinucleotid...

Full description

Bibliographic Details
Main Authors: Xiaolin Zhong, Menghao Huang, Hyeong-Geug Kim, Yang Zhang, Kushan Chowdhury, Wenjie Cai, Romil Saxena, Robert F. Schwabe, Suthat Liangpunsakul, X. Charlie Dong
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Sirtuin 6
Steatosis
Inflammation
Nonalcoholic Steatohepatitis
Deacetylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20300497

Internet

http://www.sciencedirect.com/science/article/pii/S2352345X20300497

Similar Items