Clinical Implications of Hepatitis B Virus RNA and Covalently Closed Circular DNA in Monitoring Patients with Chronic Hepatitis B Today with a Gaze into the Future: The Field Is Unprepared for a Sterilizing Cure

Clinical Implications of Hepatitis B Virus RNA and Covalently Closed Circular DNA in Monitoring Patients with Chronic Hepatitis B Today with a Gaze into the Future: The Field Is Unprepared for a Sterilizing Cure

Chronic hepatitis B virus (HBV) infection has long remained a critical global health issue. Covalently closed circular DNA (cccDNA) is a persistent form of the HBV genome that maintains HBV chronicity. Decades of extensive research resulted in the two therapeutic options currently available: nucleot...

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Bibliographic Details
Main Authors: Anastasiya Kostyusheva, Dmitry Kostyushev, Sergey Brezgin, Elena Volchkova, Vladimir Chulanov
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Genes
Subjects:
hepatitis B virus
chronic hepatitis B
pre-genomic RNA
splice variants
covalently closed circular DNA
monitoring
treatment end-points
nucleot(s)ide analogues
interferon
prediction
liver disease
Online Access:http://www.mdpi.com/2073-4425/9/10/483

Internet

http://www.mdpi.com/2073-4425/9/10/483

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