A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo

A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer in vivo

Aggressive forms of breast cancer, such as Her2+ and triple negative breast cancer (TNBC), are enriched in breast cancer stem cells (BCSC) and have limited therapeutic options. BCSC represent a key cellular reservoir for relapse, metastatic progression and therapeutic resistance. Their ability to re...

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Bibliographic Details
Main Authors: Elisabetta Bolli, John P. O'Rourke, Laura Conti, Stefania Lanzardo, Valeria Rolih, Jayne M. Christen, Giuseppina Barutello, Marco Forni, Federica Pericle, Federica Cavallo
Format: Article
Language:English
Published: Taylor & Francis Group 2018-03-01
Series:OncoImmunology
Subjects:
breast cancer
cancer stem cell
immunotherapy
virus like-particle
xct
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1408746

Internet

http://dx.doi.org/10.1080/2162402X.2017.1408746

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