Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction

Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction

Abstract Background ALAS2 (delta-aminolevulinate synthase 2) is one of the two isoenzymes catalyzing the synthesis of delta-aminolevulinic acid (ALA), which is the first precursor of heme synthesis. ALAS2-overexpressing transgenic mice (Tg mice) showed syndrome of porphyria, a series of diseases rel...

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Bibliographic Details
Main Authors: Yahui Peng, Jihong Li, Dixian Luo, Shuai Zhang, Sijia Li, Dayong Wang, Xidi Wang, Zhujun Zhang, Xue Wang, Changhui Sun, Xu Gao, Yang Hui, Rongzhang He
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Skeletal Muscle
Subjects:
Muscle atrophy
Mitochondrial dysfunction
Transgenic mice
Delta-aminolevulinate synthase 2
Online Access:https://doi.org/10.1186/s13395-021-00263-8

Internet

https://doi.org/10.1186/s13395-021-00263-8

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