Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction
Abstract Background ALAS2 (delta-aminolevulinate synthase 2) is one of the two isoenzymes catalyzing the synthesis of delta-aminolevulinic acid (ALA), which is the first precursor of heme synthesis. ALAS2-overexpressing transgenic mice (Tg mice) showed syndrome of porphyria, a series of diseases rel...
Main Authors: | Yahui Peng, Jihong Li, Dixian Luo, Shuai Zhang, Sijia Li, Dayong Wang, Xidi Wang, Zhujun Zhang, Xue Wang, Changhui Sun, Xu Gao, Yang Hui, Rongzhang He |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-03-01
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Series: | Skeletal Muscle |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13395-021-00263-8 |
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