TGR5 Activation Modulates an Inhibitory Effect on Liver Fibrosis Development Mediated by Anagliptin in Diabetic Rats

TGR5 Activation Modulates an Inhibitory Effect on Liver Fibrosis Development Mediated by Anagliptin in Diabetic Rats

Hyperglycemia and hyperinsulinemia activate the proliferative potential of hepatic stellate cells (HSCs) and promote hepatic fibrosis. Dipeptidyl peptidase-4 (DPP-4) inhibitors, antidiabetic agents, reportedly inhibit the HSC proliferation. Additionally, Takeda G protein-coupled receptor 5 (TGR5) ag...

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Bibliographic Details
Main Authors: Daisuke Kaya, Kosuke Kaji, Yuki Tsuji, Satoko Yamashita, Koh Kitagawa, Takahiro Ozutsumi, Yukihisa Fujinaga, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
dipeptidyl peptidase-4 inhibitors
hepatic stellate cells
oleanolic acid
takeda g protein-coupled receptor 5
Online Access:https://www.mdpi.com/2073-4409/8/10/1153

Internet

https://www.mdpi.com/2073-4409/8/10/1153

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