Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Summary: Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-immune proteins linked to COVID-19. Deconvolution of...

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Bibliographic Details
Main Authors: Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, Kyle R. Kays, Jamey R. Guess, Matteo Gentili, Bánk G. Fenyves, Nicole C. Charland, Anna L.K. Gonye, Irena Gushterova, Hargun K. Khanna, Thomas J. LaSalle, Kendall M. Lavin-Parsons, Brendan M. Lilley, Carl L. Lodenstein, Kasidet Manakongtreecheep, Justin D. Margolin, Brenna N. McKaig, Maricarmen Rojas-Lopez, Brian C. Russo, Nihaarika Sharma, Jessica Tantivit, Molly F. Thomas, Robert E. Gerszten, Graham S. Heimberg, Paul J. Hoover, David J. Lieb, Brian Lin, Debby Ngo, Karin Pelka, Miguel Reyes, Christopher S. Smillie, Avinash Waghray, Thomas E. Wood, Amanda S. Zajac, Lori L. Jennings, Ida Grundberg, Roby P. Bhattacharyya, Blair Alden Parry, Alexandra-Chloé Villani, Moshe Sade-Feldman, Nir Hacohen, Marcia B. Goldberg
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports Medicine
Subjects:
COVID-19 severity
death versus survival
plasma proteomics
lung epithelial cells
T cell activation
lung monocyte/macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121001154

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http://www.sciencedirect.com/science/article/pii/S2666379121001154

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