Reactive Oxygen Species Released from Hypoxic Hepatocytes Regulates MMP-2 Expression in Hepatic Stellate Cells

Reactive Oxygen Species Released from Hypoxic Hepatocytes Regulates MMP-2 Expression in Hepatic Stellate Cells

Hypoxia is a common environmental stress factor and is associated with fibrogenesis. Matrix metalloproteinase-2 (MMP-2), produced by hepatic stellate cells (HSCs), plays an important role in liver fibrogenesis. However, inconsistent results have been reported on the impact of hypoxia on MMP-2 expres...

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Bibliographic Details
Main Authors: Pingsheng Chen, Leilei Liu, Shanshan Guo, Nan Wu, Wandong Zhang, Susu Zhao, Renhua Fan, Jing Li
Format: Article
Language:English
Published: MDPI AG 2011-04-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
hepatocyte
hepatic stellate cells
liver fibrosis
reactive oxygen species
Online Access:http://www.mdpi.com/1422-0067/12/4/2434/

Internet

http://www.mdpi.com/1422-0067/12/4/2434/

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