The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry

The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry

Retinoic acid (RA) regulates the maintenance of somitogenesis symmetry. Here, the authors use a proteomic approach to identify a protein complex of Wdr5, Hdac1, Hdac2 that act together with RA and coactivator Rere/Atrophin2 and a histone methyltransferase Ehmt2 to regulate embryonic symmetry.

Bibliographic Details
Main Authors: Gonçalo C. Vilhais-Neto, Marjorie Fournier, Jean-Luc Plassat, Mihaela E. Sardiu, Anita Saraf, Jean-Marie Garnier, Mitsuji Maruhashi, Laurence Florens, Michael P. Washburn, Olivier Pourquié
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00593-6

Internet

https://doi.org/10.1038/s41467-017-00593-6

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