The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

Many neurodegenerative diseases share a common pathological feature: the deposition of amyloid-like fibrils composed of misfolded proteins. Emerging evidence suggests that these proteins may spread from cell-to-cell and encourage the propagation of neurodegeneration in a prion-like manner. Here, we...

Full description

Bibliographic Details
Main Authors: Takafumi Hasegawa, Masatoshi Konno, Toru Baba, Naoto Sugeno, Akio Kikuchi, Michiko Kobayashi, Emiko Miura, Nobuyuki Tanaka, Keiichi Tamai, Katsutoshi Furukawa, Hiroyuki Arai, Fumiaki Mori, Koichi Wakabayashi, Masashi Aoki, Yasuto Itoyama, Atsushi Takeda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3245276?pdf=render

Internet

http://europepmc.org/articles/PMC3245276?pdf=render

Similar Items