CD8+ T cells and IFN-γ mediate the time-dependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria.

CD8+ T cells and IFN-γ mediate the time-dependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria.

BACKGROUND: Infection with Plasmodium berghei ANKA (PbA) in susceptible mice induces a syndrome called experimental cerebral malaria (ECM) with severe pathologies occurring in various mouse organs. Immune mediators such as T cells or cytokines have been implicated in the pathogenesis of ECM. Red blo...

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Bibliographic Details
Main Authors: Carla Claser, Benoît Malleret, Sin Yee Gun, Alicia Yoke Wei Wong, Zi Wei Chang, Pearline Teo, Peter Chi Ee See, Shanshan Wu Howland, Florent Ginhoux, Laurent Rénia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3073989?pdf=render

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http://europepmc.org/articles/PMC3073989?pdf=render

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