Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists

Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists

Nociceptin/orphanin FQ controls several functions, including pain transmission, via stimulation of the N/OFQ peptide (NOP) receptor. Here we tested the hypothesis that NOP biased agonism may be instrumental for identifying innovative analgesics. In vitro experiments were performed with the dynamic m...

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Bibliographic Details
Main Authors: Joaquim Azevedo Neto, Chiara Ruzza, Chiara Sturaro, Davide Malfacini, Salvatore Pacifico, Nurulain T. Zaveri, Girolamo Calò
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neuroscience
Subjects:
NOP receptor
nociceptin/orphanin FQ
functional selectivity
mice
β arrestin 2 knockout mice
MCOPPB
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.657153/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.657153/full

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