Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer’s disease (AD), shifted research towards reliable drug discovery strategies to unveil clinical candidates with higher therapeutic efficacy than single-targeting drugs. By following the mu...

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Bibliographic Details
Main Authors: Leonardo Pisani, Roberta Farina, Ramon Soto-Otero, Nunzio Denora, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Estefania Mendez-Alvarez, Cosimo Damiano Altomare, Marco Catto, Angelo Carotti
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Molecules
Subjects:
Alzheimer’s disease
cholinesterase inhibitors
coumarins
MAO inhibitors
multi-target-directed ligands
Online Access:http://www.mdpi.com/1420-3049/21/3/362

Internet

http://www.mdpi.com/1420-3049/21/3/362

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