Trypanosoma cruzi adjuvants potentiate T cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine.

Trypanosoma cruzi adjuvants potentiate T cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine.

Immunological adjuvants that induce T cell-mediate immunity (TCMI) with the least side effects are needed for the development of human vaccines. Glycoinositolphospholipids (GIPL) and CpGs oligodeoxynucleotides (CpG ODNs) derived from the protozoa parasite Trypanosoma cruzi induce potent pro-inflamma...

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Bibliographic Details
Main Authors: Caroline Junqueira, Ana Tereza Guerrero, Bruno Galvão-Filho, Warrison A Andrade, Ana Paula C Salgado, Thiago M Cunha, Catherine Ropert, Marco Antônio Campos, Marcus L O Penido, Lúcia Mendonça-Previato, José Oswaldo Previato, Gerd Ritter, Fernando Q Cunha, Ricardo T Gazzinelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3342165?pdf=render

Internet

http://europepmc.org/articles/PMC3342165?pdf=render

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