A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunomodulatory receptors expressed on cells of the hematopoietic lineage. Here the authors demonstrate an approach for the identification of the glycan ligands of Siglecs, which is also applicable to other families of glycan...

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Bibliographic Details
Main Authors: Emily Rodrigues, Jaesoo Jung, Heajin Park, Caleb Loo, Sepideh Soukhtehzari, Elena N. Kitova, Fahima Mozaneh, Gour Daskhan, Edward N. Schmidt, Vivian Aghanya, Susmita Sarkar, Laura Streith, Chris D. St. Laurent, Linh Nguyen, Jean-Philippe Julien, Lori J. West, Karla C. Williams, John S. Klassen, Matthew S. Macauley
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18907-6

Internet

https://doi.org/10.1038/s41467-020-18907-6

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