RNAi-mediated silencing of the Bmi-1 gene causes growth inhibition and enhances doxorubicin-induced apoptosis in MCF-7 cells

RNAi-mediated silencing of the Bmi-1 gene causes growth inhibition and enhances doxorubicin-induced apoptosis in MCF-7 cells

The oncogene Bmi-1 is a member of the Polycomb group gene family. Its expression is found to be greatly increased in a number of malignant tumors including breast cancer. This could suggest Bmi-1 as a potent therapeutic target. In this study, RNAi was introduced to down-regulate the expression of Bm...

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Bibliographic Details
Main Authors: Xiang-mei Wu, Xing Liu, You-quan Bu, Joyeeta Sengupta, Hong-juan Cui, Fa-ping Yi, Tao Liu, Chen-fu Yuan, Yan-yan Shi, Fang-zhou Song
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2009-01-01
Series:Genetics and Molecular Biology
Subjects:
RNA interference
Bmi-1
retrovirus vector
doxorubicin
breast cancer
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000400004

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000400004

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