SOX2 promotes hypoxia-induced breast cancer cell migration by inducing NEDD9 expression and subsequent activation of Rac1/HIF-1α signaling

SOX2 promotes hypoxia-induced breast cancer cell migration by inducing NEDD9 expression and subsequent activation of Rac1/HIF-1α signaling

Abstract Background Hypoxia, a major condition associated with the tumor microenvironment, stimulates the migration of cancer cells. SOX2 is a powerful transcription factor that shows higher expression in several cancers, however, its role in hypoxia-induced breast cancer cell migration remains larg...

Full description

Bibliographic Details
Main Authors: Yueyuan Wang, Maria Bibi, Pengxiang Min, Wenjie Deng, Yujie Zhang, Jun Du
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
Hypoxia
Migration
Breast cancer cells
SOX2
NEDD9
Online Access:http://link.springer.com/article/10.1186/s11658-019-0180-y

Internet

http://link.springer.com/article/10.1186/s11658-019-0180-y

Similar Items