Comparing Pathways of Bradykinin Formation in Whole Blood From Healthy Volunteers and Patients With Hereditary Angioedema Due to C1 Inhibitor Deficiency

Comparing Pathways of Bradykinin Formation in Whole Blood From Healthy Volunteers and Patients With Hereditary Angioedema Due to C1 Inhibitor Deficiency

Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or −2 only) to investigate kinin formation. An enzyme immunoassay for...

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Bibliographic Details
Main Authors: Xavier Charest-Morin, Jacques Hébert, Georges-Étienne Rivard, Arnaud Bonnefoy, Eric Wagner, François Marceau
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
B2 receptors
bradykinin
hereditary angioedema with C1 inhibitor deficiency
kallikreins
tissue plasminogen activator
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02183/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02183/full

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