Inhibition of Alk signaling promotes the induction of human salivary-gland-derived organoids

Hyposalivation and xerostomia are the cause of several morbidities, such as dental caries, painful mucositis, oral fungal infections, sialadenitis and dysphagia. For these reasons, preservation of normal saliva secretion is critical for the maintenance of functionally normal oral homeostasis and for...

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Bibliographic Details
Main Authors: Shohei Yoshimoto, Junko Yoshizumi, Hiromasa Anzai, Koichiro Morishita, Kazuhiko Okamura, Akimitsu Hiraki, Shuichi Hashimoto
Format: Article
Language:English
Published: The Company of Biologists 2020-09-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/13/9/dmm045054