The impact of Folate Pathway Polymorphisms Combined to Nutritional Deficiency As a Maternal Predisposition Factor for Down Syndrome

The impact of Folate Pathway Polymorphisms Combined to Nutritional Deficiency As a Maternal Predisposition Factor for Down Syndrome

Polymorphisms in genes encoding folate metabolizing enzymes have been linked to an increased risk of maternal chromosomal nondisjunction in several populations. With the purpose of evaluating this relationship, we compared the frequencies of 677C>T and 1298A>C polymorphisms in the methylenetet...

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Main Authors: C. B. Santos-Rebouças, J. C. Corrêa, A. Bonomo, N. Fintelman-Rodrigues, K. C. V. Moura, C. S. C. Rodrigues, J. M. Santos, M. M. G. Pimentel
Format: Article
Language:English
Published: Hindawi Limited 2008-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2008/487023

Internet

http://dx.doi.org/10.1155/2008/487023

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