New insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa.

Sialidases are glycohydrolytic enzymes present from virus to mammals that remove sialic acid from oligosaccharide chains. Four different sialidase forms are known in vertebrates: the lysosomal NEU1, the cytosolic NEU2 and the membrane-associated NEU3 and NEU4. These enzymes modulate the cell sialic...

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Bibliographic Details
Main Authors: Edoardo Giacopuzzi, Roberto Bresciani, Roland Schauer, Eugenio Monti, Giuseppe Borsani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3431349?pdf=render