Deficiency of NOD1 Improves the β-Adrenergic Modulation of Ca2+ Handling in a Mouse Model of Heart Failure

Deficiency of NOD1 Improves the β-Adrenergic Modulation of Ca2+ Handling in a Mouse Model of Heart Failure

Heart failure (HF) is a complex syndrome characterized by cardiac dysfunction, Ca2+ mishandling, and chronic activation of the innate immune system. Reduced cardiac output in HF leads to compensatory mechanisms via activation of the adrenergic nervous system. In turn, chronic adrenergic overstimulat...

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Bibliographic Details
Main Authors: Almudena Val-Blasco, Jose A. Navarro-García, Maria Tamayo, Maria J. Piedras, Patricia Prieto, Carmen Delgado, Gema Ruiz-Hurtado, Laura Rozas-Romero, Marta Gil-Fernández, Carlos Zaragoza, Lisardo Boscá, María Fernández-Velasco
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
β-adrenergic response
heart failure
NOD1
Ca2+ handling
innate immune system
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00702/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00702/full

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