VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes

VEGF can protect against blood brain barrier dysfunction, dendritic spine loss and spatial memory impairment in an experimental model of diabetes

Clinical and experimental studies have shown a clear link between diabetes, vascular dysfunction and cognitive impairment. However, the molecular underpinnings of this association remain unclear. Since vascular endothelial growth factor (VEGF) signaling is important for maintaining vascular integrit...

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Bibliographic Details
Main Authors: Stephanie L. Taylor, Dustin Trudeau, Brendan Arnold, Joshua Wang, Kim Gerrow, Kieran Summerfeldt, Andrew Holmes, Akram Zamani, Patricia S. Brocardo, Craig E. Brown
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Neurobiology of Disease
Subjects:
Diabetes
Vascular endothelial growth factor
Blood brain barrier
Dendritic spines
Hippocampus
Learning and memory
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000947

Internet

http://www.sciencedirect.com/science/article/pii/S0969996115000947

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