Carveol a Naturally-Derived Potent and Emerging Nrf2 Activator Protects Against Acetaminophen-Induced Hepatotoxicity

Carveol a Naturally-Derived Potent and Emerging Nrf2 Activator Protects Against Acetaminophen-Induced Hepatotoxicity

Acetaminophen (N-acetyl p-aminophenol or APAP) is used worldwide for its antipyretic and anti-inflammatory potential. However, APAP overdose sometimes causes severe liver damage. In this study, we elucidated the protective effects of carveol in liver injury, using molecular and in silico approaches....

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Bibliographic Details
Main Authors: Zaif Ur Rahman, Lina Tariq Al Kury, Abdullah Alattar, Zhen Tan, Reem Alshaman, Imran Malik, Haroon Badshah, Zia Uddin, Atif Ali Khan Khalil, Naveed Muhammad, Saifullah Khan, Amjad Ali, Fawad Ali Shah, Jing Bo Li, Shupeng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
acetaminophen
carveol
hepatotoxicity
anti-inflammatory
Nrf2 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.621538/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.621538/full

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