Functional characterization of a bioengineered liver after heterotopic implantation in pigs

Functional characterization of a bioengineered liver after heterotopic implantation in pigs

Anderson et al. demonstrate a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver (BEL) scaffold previously reendothelialized with HUVECs. This study constitutes an important advance in the effort to generate transplantable livers of a clinically relevant size fo...

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Main Authors: Brett D. Anderson, Erek D. Nelson, DongJin Joo, Bruce P. Amiot, Aleksandr A. Katane, Alyssa Mendenhall, Benjamin G. Steiner, Aron R. Stumbras, Victoria L. Nelson, R. Noelle Palumbo, Thomas W. Gilbert, Dominique S. Davidow, Jeffrey J. Ross, Scott L. Nyberg
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02665-2
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spelling doaj-c0c41e41b8204756bab603753cae52e22021-10-10T11:13:25ZengNature Publishing GroupCommunications Biology2399-36422021-10-014111010.1038/s42003-021-02665-2Functional characterization of a bioengineered liver after heterotopic implantation in pigsBrett D. Anderson0Erek D. Nelson1DongJin Joo2Bruce P. Amiot3Aleksandr A. Katane4Alyssa Mendenhall5Benjamin G. Steiner6Aron R. Stumbras7Victoria L. Nelson8R. Noelle Palumbo9Thomas W. Gilbert10Dominique S. Davidow11Jeffrey J. Ross12Scott L. Nyberg13Miromatrix Medical IncDepartment of Surgery, Mayo ClinicDepartment of Surgery, Mayo ClinicDepartment of Surgery, Mayo ClinicMiromatrix Medical IncMiromatrix Medical IncMiromatrix Medical IncMiromatrix Medical IncMiromatrix Medical IncMiromatrix Medical IncMiromatrix Medical IncMiromatrix Medical IncMiromatrix Medical IncDepartment of Surgery, Mayo ClinicAnderson et al. demonstrate a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver (BEL) scaffold previously reendothelialized with HUVECs. This study constitutes an important advance in the effort to generate transplantable livers of a clinically relevant size for humans.https://doi.org/10.1038/s42003-021-02665-2
collection DOAJ
language English
format Article
sources DOAJ
author Brett D. Anderson
Erek D. Nelson
DongJin Joo
Bruce P. Amiot
Aleksandr A. Katane
Alyssa Mendenhall
Benjamin G. Steiner
Aron R. Stumbras
Victoria L. Nelson
R. Noelle Palumbo
Thomas W. Gilbert
Dominique S. Davidow
Jeffrey J. Ross
Scott L. Nyberg
spellingShingle Brett D. Anderson
Erek D. Nelson
DongJin Joo
Bruce P. Amiot
Aleksandr A. Katane
Alyssa Mendenhall
Benjamin G. Steiner
Aron R. Stumbras
Victoria L. Nelson
R. Noelle Palumbo
Thomas W. Gilbert
Dominique S. Davidow
Jeffrey J. Ross
Scott L. Nyberg
Functional characterization of a bioengineered liver after heterotopic implantation in pigs
Communications Biology
author_facet Brett D. Anderson
Erek D. Nelson
DongJin Joo
Bruce P. Amiot
Aleksandr A. Katane
Alyssa Mendenhall
Benjamin G. Steiner
Aron R. Stumbras
Victoria L. Nelson
R. Noelle Palumbo
Thomas W. Gilbert
Dominique S. Davidow
Jeffrey J. Ross
Scott L. Nyberg
author_sort Brett D. Anderson
title Functional characterization of a bioengineered liver after heterotopic implantation in pigs
title_short Functional characterization of a bioengineered liver after heterotopic implantation in pigs
title_full Functional characterization of a bioengineered liver after heterotopic implantation in pigs
title_fullStr Functional characterization of a bioengineered liver after heterotopic implantation in pigs
title_full_unstemmed Functional characterization of a bioengineered liver after heterotopic implantation in pigs
title_sort functional characterization of a bioengineered liver after heterotopic implantation in pigs
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-10-01
description Anderson et al. demonstrate a method for seeding and engrafting primary porcine hepatocytes into a bioengineered liver (BEL) scaffold previously reendothelialized with HUVECs. This study constitutes an important advance in the effort to generate transplantable livers of a clinically relevant size for humans.
url https://doi.org/10.1038/s42003-021-02665-2
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